Temperance "Bones" Brennan

    Portrayed by Emily Deschanel

Dr. Temperance Brennan (Season 1–) works as a forensic anthropologist at the Jeffersonian Institute in Washington, D.C. and is also a best-selling novelist. Nicknamed "Bones" by FBI Special Agent Seeley Booth, who is also her on and off love interest. Brennan and Booth work together on FBI cases concerning recently found human remains. Although she is an expert in her field, Brennan is socially awkward and has limited knowledge about pop culture. Her birth name was Joy Keenan. Brennan's parents had left her and her older brother Russ when she was fifteen. She also thinks herself to be extremely rational. She is never (barring one episode, the Doctor in the Photo) the one to get the most emotionally attached to the cases and/or the people involved. She is currently expecting Booth's child. (Season 7)

Seeley Booth

    Portrayed by David Boreanaz

Special Agent Seeley Booth (Season 1–) is a former Army sniper with the Rangers, who is currently an agent with the FBI. He frequently consults with Dr. Brennan and her team in his investigations but prefers a more humane and interpersonal approach than Dr. Brennan's hard, objective and analytical approach. He is shown to be world-wise and socially at ease with people. Booth has a son, Parker, with his ex. At the end of Season 4, it is revealed Booth has a brain tumor causing him to hallucinate. In season 5, Booth admits to Dr. Saroyan that he is in love with Brennan. It is also revealed that he is a direct descendant of presidential assassin John Wilkes Booth, a fact that upsets him greatly.In the season 6 finale it is revealed that Dr. Brennan is expecting Booth's child after they had spent the night together both suffering from the death of Vincent Nigel-Murray and sleeping together.

Angela Montenegro

    Portrayed by Michaela Conlin

Angela Montenegro (Season 1–) works as a forensic artist at the Jeffersonian Institute and is Dr. Brennan's best friend.She changed her name in her late teens,but only one girl knows her real name. Angela is Dr. Brennan's team specialist in craniofacial reconstruction and can generate holograms using her 3-dimensional graphics program (The Angelator) to simulate various scenarios of a crime. She is open, friendly and caring, and constantly tries to draw Dr. Brennan out of the lab. In the episode "The Man in the Fallout Shelter", it was revealed Angela's father is Billy Gibbons, a member of the band ZZ Top. Her middle name is supposedly "Pearly Gates", which is also the name of Billy Gibbon's 1959 Les Paul Guitar. In Season five she marries Dr. Jack Hodgins while in jail for an outstanding warrant. During the ceremony, she whispers her real name to the justice of the peace, though it is never revealed to the viewers. In season 6 we learn that she is pregnant with her first child, and her son, Michael Staccato Vincent Hodgins, who was born during the season finale.

Jack Hodgins

    Portrayed by T. J. Thyne

Dr. Jack Hodgins (Season 1–) is an entomologist and is also an expert on spores and minerals, but conspiracy theories are his hobby. He is one of the more normal person(s) in the group, and helps teach Zack how to be socially normal. His family is extremely wealthy as he is the last living heir to leader of the Cantalever Group,but Hodgins wishes for his wealth to stay a secret to Dr.Brennan to be treated fairly,but when he and Temperance are buried alive by The Gravedigger. In season 5, he marries Angela Montenegro while in jail for an eight-year-old warrant. His son with Angela, Michael Staccato Vincent Hodgins, was born in the season 6 finale.

Lance Sweets

    Portrayed by John Francis Daley

Dr. Lance Sweets (Season 3–) is an F.B.I. psychologist assigned to Booth and Brennan after Booth arrests Brennan's father and later her brother. The character made his first appearance in Season 3, Episode 4, "The Secret in the Soil", and became a main cast member in Episode 9, "The Santa in the Slush". When he joins the cast, he is 22 years old, which is remarkable for a Ph.D.; but he looks much younger, which causes Booth to be rude and condescending. While he is annoyed at Booth, Sweets stands his ground, even coaxing Booth and Brennan into going on a double date with him and his tropical-fish specialist girlfriend,April. Sweets and April break up shortly after the date, and Booth and Brennan become something of a "crying shoulder" in a reciprocal relationship. He later falls in love with lab assistant Daisy Wick. Also, Sweets is trained as a profiler and has assisted Booth and Bones, finding even dull lab-work new and exciting. As part of Season 3's storyline concerning the serial killers collectively known as The Gormogon, Sweets helps Booth and Brennan identify possible victims and profile the Gormogon. He can talk effectively with Booth and Brennan in the language appropriate to each; but he has an unfortunate tendency to use language similar to Valleyspeak when testifying in court, which is inappropriate for someone of his age and accomplishments. He is also a big part in the matchmaking for Brennan and Booth and writes a book about them, which he discards when he learns from them that it was based on a false premise.

While in the psychiatric institute, Zack was regularly visited by Hodgins and Dr. Sweets. Some time later, Zack broke out of the psychiatric ward in order to help his friends solve a case. After the case was solved, Zack willingly returned to the psychiatric facility. Zack later told Sweets that he did not kill anyone, but told Gormogon where the victim was in order to murder and cannibalize them. Sweets wanted to tell the others, but Zack told him not to do so to avoid being sent to a "regular jail" as he "would not do well in prison".

Camille Saroyan

    Portrayed by Tamara Taylor

Dr. Camille Saroyan (Season 2–), always called Cam, is a Pathologist and the Head of the Forensic Division at Jeffersonian Institute. She was born in The Bronx, although she does not have a noticeable New York accent, and was previously a coroner in New York. Dr. Goodman appeared only as an administrator, but Cam is a full partner with Brennan's team, handling bodies with flesh attached. She was introduced Season 2, Episode 1, after being hired by Dr. Goodman while Dr. Brennan was on vacation. At first, she and the team have an uneasy working relationship because she is a hands-on manager and insists on being kept informed at all times. She had a romantic relationship with Booth when she was still in New York, which was briefly rekindled until Booth decided that his "high risk" life put anyone close to him in danger.